bookmark_borderFlavonoids for Treating Viral Acute Respiratory Tract Infections



Based on their chemical structure, flavonoids can be subclassified into six principal subclasses: flavonols (mainly including quercetin, kaempferol, myricetin, and isorhamnetin), flavones (apigenin and luteolin), flavanones (hesperetin and naringenin), flavan−3-ols (catechin, epicatechin, epigallocatechin, epicatechin−3-gallate, and epigallocatechin−3-gallate), anthocyanins (cyanidin, delphinidin, malvidin, pelargonidin, petunidin, and peonidin), and isoflavones (genistein and daidzein.

bookmark_borderPhytotherapy for treatment of cytokine storm in COVID-19

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5.14.2 Anti-inflammatory and health mediated properties of Phyllanthus emblica

Studies showed that administration of PE extract protected the lung from the inflammatory injury by altering the IL-1β/miR-i101/Lin28B signaling pathway [235]. It also inhibited the benzopyrene induced pre-cancerous lung lesions by downregulating the pro-inflammatory cytokine expression viz. IL-1β, IL-6, TNF-α and MIP-2 in lung tissues. It also suppressed edema in rats in a dose dependent manner.